In the current study, triple layer matrix tablets were formulated by using HPMC K100, K15, E 50, and Eudragit L 100 as barrier layers. The main motto of the study is to increase the mean dissolution time and decrease the dissolution efficiency. Triple layer tablets have been focused to promote zero order release unlike mono layer tablets. As mono layer tablets experience prolonged drug release with initial burst release, Triple layer matrix tablets have come into existence to overcome the burst release problems of conventional tablets. FTIR studies revealed that there is no interaction between the excipients and drug used in this triple layer tablet formulations. The triple layer tablets were evaluated by physiochemical parameters like thickness, hardness, friability and disintegration time. Differences in dissolution characteristics of formulations F1 to F5 were observed. The two barrier layers present at up and bottom of tablet will restrict the release of drug from the tablet allowing prolonged and slow release of drug. Eventually, atenolol triple layer tablets can be suitable for sustained release of drug over prolong period of time.
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